I would say a fumble when a team is trying to run out the clock is pretty damn high on the list of things to blame, rather than if we had taken X more secs per play off they clock they would've only had X secs left, etc. They still would've had plenty of time regardless.
MSU would've had to use both of their timeouts if Otis doesn't fumble. Instead he fumbles and they have two TO's left and over a minute.