I'll defer to your inpatient and ICU/CCU experience. I know nothing about these two meds in combination. All meds as you know have side effects more so in patients with certain conditions. What I do know is Plaquenil has been one med that has been the standard of care in treating rheumatology patient specifically for RA and SLE. The reason it is still widely used over 70+ years......it's effective and it has minimal side effects. 200 mg BID daily can and is tolerated for years. Main issues I've seen to discontinue the med is GI issues or a rash outbreak. To contradict Dr. Drew Pinsky last night on TV it doesn't not cause corneal deposits. Slight risk taken long term greater than 12 month of retinal toxicity or called maculopathy. Z-Pak is what it is. It works. It is one of the top Rx'd antibiotics in this country.
Now if that combo is the only arrow you have in your quiver or just Plaquenil alone...........you let it fly.